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Ricerche scientifiche

A livello divulgativo in questa pagina potrete trovare gli studi e le ricerche scientifiche che hanno avuto il preciso scopo di comprovare e validare le proprietà benefiche di alcuni selezionate materie prime e principi attivi.

È bene ricordare che gli integratori alimentari non hanno proprietà curative, ma possono contribuire al benessere dell’organismo ottimizzando lo stato nutrizionale oppure contribuendo con l’apporto di nutrienti e sostanze utili al normale sviluppo e mantenimento in buona salute dell’organismo.

Semi di lino

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:

I Semi di Lino Biologici sono particolarmente ricchi di Omega 3 e Lignani. Questi ultimi due nutrienti hanno mostrato in numerosi studi scientifici la capacità di diminuire colesterolo, processi infiammatori, ipertensione e dislipidemie (“Nutrients 2016,8(3),136”).

Curcuma

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:​

  1. Madhu K. Et al. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2012 Dec 16.
  2. Derosa G. et al. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 111:394-404. doi: 10.1016/j.phrs.2016.07.004, 2016.
  3. Shep D. et al. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. 2019 Apr 11;20(1):214. doi: 10.1186/s13063-019-3327-2, 2019.
  4. Yang Y.S. et al. Lipid-Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Phytother Res. 2014 Aug 6. doi: 10.1002/ptr.5197, 2014.
  5. Tabrizi R. et al. The effects of curcumin on glycemic control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Curr Pharm Des. 2018 Aug 28. doi: 10.2174/1381612824666180828162053, 2018.
  6. Pungcharoenkol K. Et al. Effect of Different Curcuminoid Supplement Dosages on Total In Vivo Antioxidant Capacity and Cholesterol Levels of Healthy Human Subjects. Phytother Res. 2011 Jul 27. doi: 10.1002/ptr.3608, 2011.

  7. Jimenez Osorio A.S. et al. The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study. J Ren Nutr. 2016 Feb 22. pii: S1051-2276(16)00014-5. doi: 10.1053/j.jrn.2016.01.013, 2016.

  8. Santos Parker J.R. et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress. Aging (Albany NY). 2017 Jan 3;9(1):187-208. doi: 10.18632/aging.101149, 2017.

Boswellia

1. Paper scientifici inerenti all'effetto Antinfiammatorio, fonti:

  1. Vishal A.A. et al. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci.;8(7):615-22, 2011.
  2. Chilelli N.C. et al. Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes. Nutrients. 2016 Nov 21;8(11). pii: E745, 2016.
  3. Haroyan A. et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018 Jan 9;18(1):7. doi: 10.1186/s12906-017-2062-z, 2018.

Camelina Sativa

1. Paper scientifici inerenti all'effetto Antiossidante, fonti:

  1. Hermier D. et al. Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids During the Metabolic Syndrome Onset in Mice. J Agric Food Chem, 68 (3), 788-798, 2020 Jan.

  2. Nutrition & Food Research, published online 12/04/2018, DOI: 10.1002/mnfr.201701042. Intake of fish alters the size and composition of HDL particles and camelina sativa oil decreases IDL particle concentration in subjects with impaired glucose metabolism. Molecular .

  3. Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):51-61. doi: 10.1016/j.numecd.2018.10.002. Epub 2018 Oct 11. The effect of camelina sativa oil and fish intakes on fatty acid compositions of blood lipid fractions.

2. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:​

  1. Atherosclerosis. 2019 Feb;281:56-61. doi: 10.1016/j.atherosclerosis.2018.12.017. Epub 2018 Dec 23. The effect of intakes of fish and Camelina sativa oil on atherogenic and anti-atherogenic functions of LDL and HDL particles: A randomized controlled trial.
  2. Manninen S.M. et al. Intake of Fatty Fish Alters the Size and the Concentration of Lipid Components of HDL Particles and Camelina Sativa Oil Decreases IDL Particle Concentration in Subjects with Impaired Glucose Metabolism. Mol Nutr Food Res. 2018 May;62(10):e1701042. doi: 10.1002/mnfr.201701042, 2018.
  3. Lipids. 2019 Aug;54(8):453-464. doi: 10.1002/lipd.12176. Epub 2019 Jul 1. Camelina sativa Oil, Fatty Fish, and Lean Fish Do Not Markedly Affect Urinary Prostanoids in Subjects with Impaired Glucose Metabolism.
  4. Nutr Diabetes. 2019 Jan 9;9(1):1. doi: 10.1038/s41387-018-0069-2. The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial.
  5. Karvonen H.M. et al. Effect of alpha-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. Metabolism. 2002 Oct;51(10):1253-60, 2002.

Nigella

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:

  1. Isik H. et al. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010;19(3):206-11. doi: 10.1159/000285289
  2. Kheirouri S. et al. Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis. Immunol Invest. 2016 May;45(4):271-83. doi: 10.3109/08820139.2016.1153649.
  3. Salimzadeh A. et al. Effect of an orally formulated processed black cumin, from Iranian traditional medicine pharmacopoeia, in relieving symptoms of knee osteoarthritis: A prospective, randomized, double-blind and placebo-controlled clinical trial. Int J Rheum Dis. 2017 Jun;20(6):691-701. doi: 10.1111/1756-185X.13066.
  4. Sabzghabaee A.M. et al. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arch. 2012;66(3):198-200.
  5. Ahmad Alobaidi A.H. et al. Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial. Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):68-74.
  6. Sahebkar A. et al. Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacol Res. 2016 Apr;106:37-50. doi: 10.1016/j.phrs.2016.02.008.

Licopene

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:​

  1. Kim O.Y. et al. Independent inverse relationship between serum lycopene concentration and arterial stiffness. Atherosclerosis. 2009 Aug 13, 2009.
  2. Shardell M.D. et al. Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey. Nutr Res. 2011 Mar;31(3):178-89, 2011.
  3. Chen J. et al. Effect of lycopene supplementation on oxidative stress: an exploratory systematic review and meta-analysis of randomized controlled trials. J Med Food. 2013 May;16(5):361-74. doi: 10.1089/jmf.2012.2682, 2013.4)Li X. et al. Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies. Sci Rep. 2014 May 22;4:5031. doi: 10.1038/srep05031, 2014.

Vitamina D

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:

  1. Bolland M.J. et al. Vitamin D insufficiency and health outcomes over 5 y in older women. Am J Clin Nutr. 2009 Nov 11. [Epub ahead of print].

  2. Mulligan L.M. et al. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2009 Oct 19.

  3. Sim J.J. et al. Vitamin D deficiency and anemia: a cross-sectional study. Ann Hematol. 2009 Oct 20.

Vitamina E

1. Paper scientifici inerenti all'effetto benefico sull'organismo, fonti:

  1. Rondanelli M. et al. Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging. Int J Mol Sci. 16(10):23227-49. doi: 10.3390/ijms161023227, 2015.

  2. Jayedi A. et al. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies. Adv Nutr. 2018 Nov 1;9(6):701-716. doi: 10.1093/advances/nmy040, 2018.

  3. Miranda C.T.O.F. et al. Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease. J Nutr Metab. 2018 Dec 11;2018:6104169. doi: 10.1155/2018/6104169. eCollection 2018.

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